Cyber-Physical Systems (CPS) consist of large-scale interconnected systems of heterogeneous components interacting with their physical environments. There are a multitude of CPS devices and applications being deployed to serve critical functions in our lives. The security of CPS becomes extremely important. This workshop will provide a platform for professionals from academia, government, and industry to discuss how to address the increasing security challenges facing CPS. Besides invited talks, we also seek novel submissions describing theoretical and practical security solutions to CPS. Papers that are pertinent to the security of embedded systems, SCADA, smart grid, and critical infrastructure networks are all welcome, especially in the domains of energy and transportation.