BEGIN:VCALENDAR VERSION:2.0 PRODID:icalendar-ruby CALSCALE:GREGORIAN BEGIN:VEVENT DTSTAMP:20260618T221833Z UID:2a27b365-9d67-430d-8ded-04447f229d6f DTSTART:20250602T070000Z DTEND:20250605T150000Z DESCRIPTION:logo\nAbout\nLecturers\nProgram\nVenue\nRegistration\nAccommoda tion\nContact\n6th Hands-on Computational Enzyme Design Course\n2 - 5 JUNE \, 2025\, Brno\, CZECHIA\nIcon_In-Person_white\nIN-PERSON\nAbout the cours e\nDo you need to engineer your protein of interest? Do you wish to employ user-friendly one-stop-shop software tools for the design of mutations an d libraries\, but do not want to spend time on tedious installations or us e the Unix command-line? This interactive course will provide essential th eory on different areas of enzyme engineering and hands-on experience with several software tools suitable for mining new enzymes\, and engineering the activity\, specificity\, enantioselectivity\, stability\, and solubili ty of enzymes. To remain at the cutting edge of scientific advancements\, we will also explore the applications of machine learning techniques and q uantum computing in enzyme design.\n\nYou will have the chance to learn fr om the developers or experienced users of those tools\, and discuss the op timal ways to set-up calculations and adequately interpret the results. At the end of this 4-day course\, you will be able to design different prope rties of proteins for your academic research or commercial applications on your own.\n\nSoftware and databases covered: AggreProt\, AlphaFill\, Alph aFold\, Caver\, CaverDock\, Caver Web\, ChannelsDB\, EnzymeMiner\, ESMFold \, FireProt\, FireProtASR\, FireProtDB\, HotSpot Wizard\, LoopGrafter\, Pr oteinMPNN\, RF Diffusion\, Solubis\, SoluProt and SoluProtMutDB. Our web-t ools integrate multiple individual software\, and altogether\, you will ge t automated access to more than 50 computational methods and 15 databases. \n\nWho should participate\nThe course is primarily meant for protein and metabolic engineers with no prior experience in computer modeling and bioi nformatics. The experts willing to broaden their current computational pro tein design toolbox will also benefit from this course. Doctoral students\ , postdocs\, and staff members from both academia and companies are welcom e.\n\nPrevious editions\nThe 1st Hands-on Computational Enzyme Design Cour se was hosted in the classical in-person format and took place in Brno\, C zech Republic\, in February 2020. We had more than 30 participants from 12 countries\, about 70% from academia (ex.: Zurich University\, KTH Royal I nstitute\, Georgia Institute of Technology) and 30% from industry (ex.: Pf izer\, Novartis Pharma\, Johnson &\; Johnson).\n\nThe following edition s of the Hands-on Computational Enzyme Design Course took place in May 202 1 (online)\, May 2022 (online)\, May 2023 (hybrid mode)\, and the 5th in February 2024 (online). In this last one we trained nearly 80 participants from 22 countries\, also from academia (72%) and industry (28%)\, and we granted 4 scholarships.\n\nThe participants learned the background theory of computational enzyme design\, practiced the exercises provided and work ed on their own problems of interest\, always assisted by our team of expe rts. Knowledge and experience were exchanged in a friendly and interactive environment. The feedback was extremely positive in both on-site and onli ne editions. Here is a selection of testimonies from the participants:\n\n Excellent course set up! It helped me to understand more the bioinformatic s tools and encouraged me to use them in the future. (Academia\, online)\n ‌‌The course is a very good introduction to computational enzyme engin eering for non-bioinformaticians. The open discussions and useful computer exercises gave me a better understanding of the field (…) Besides the q uality of the course contents\, I have to say the social program and hospi tality of the organizers were superb. I would definitely recommend it! (Ac ademia\, in-person)\n‌Excellent organization and incredibly motivated tu tors\; great way to familiarize yourself with computational approaches for enzyme engineering. (Industry\, in-person)\nOverall I was highly impresse d by the great organization of this course. Everything was prepared well i n order to avoid technical issues successfully. I mostly appreciated that the tutorials were recorded and could be played and paused individually. T here was always enough time to follow the tutorial and the discussion of o pen questions. (Industry\, online)\nThis course was extremely well organiz ed\, and covered the basics and more advanced bioinformatics tools. I can now more confidently use these tools and apply them to my own enzymes! (Ac ademia\, online)\nThis is one of the best courses that I have taken in my long scientific career. All instructors are highly qualified and not only experts in their respective areas\, but also have insights and can address any challenge in different research areas. All scientists and instructors are very friendly yet very diverse\, which enriches the cultural diversit y (…). This is a highly recommended course designed and developed by one of the leading groups in Protein Engineering in Europe and Worldwide. (Ac ademia\, in-person) LOCATION:the University Campus Bohunice (Masaryk University) SUMMARY:6th Hands-on Computational Enzyme Design Course URL;VALUE=URI:https://loschmidt.chemi.muni.cz/academy/ END:VEVENT END:VCALENDAR