BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
BEGIN:VEVENT
DTSTAMP:20260905T103307Z
UID:357aaf57-73ed-407e-be85-c032f7eb91ca
DTSTART:20261203T090000Z
DTEND:20261203T170000Z
DESCRIPTION:Genomic variation can perturb normal biological processes throu
 gh diverse\, context-dependent mechanisms\, making multidimensional data i
 ntegration essential for interpreting variant effects. While millions of m
 issense variants exist within the human proteome\, only a tiny fraction cu
 rrently possess clinical annotations.\n\nProtVar\, developed by the Protei
 n Function Development at EMBL-EBI\, is a human variant annotation and ass
 essment resource that bridges genomic coordinates\, protein sequences\, st
 ructures\, and functional data. It aggregates curated insights and predict
 ions from sources including UniProt\, Ensembl\, PDBe\, Open Targets\, and 
 AlphaFoldDB.\n\nHaving recently evolved from a single variant lookup tool 
 into a proteome-wide discovery engine\, ProtVar now allows researchers to 
 search\, filter\, and contextualise over 500 million potential human misse
 nse variants. Featuring new AI-powered real-time semantic search\, ProtVar
  maps plain language queries such as disease terms\, pathways\, or drug re
 sponses e.g.\, "Warfarin sensitivity"\, directly to functional and structu
 ral mechanisms.\n\nThis webinar will provide practical guidance on using P
 rotVar to explore missense variation. It will feature live demonstrations 
 of its new discovery features\, including real-time AI searching\, multi-c
 riteria filtering across all potential variants in the proteome\, structur
 al visualisations\, and data export options.  \n  \nThis event is part of 
 the broader ["UniProt 2026-2027"](https://www.ebi.ac.uk/training/events/un
 iprot-2026-2027/) series. You can follow the link for more information abo
 ut the series and its webinars.
LOCATION:\, 
SUMMARY:Discovery and Variant Effect Prediction with the next generation of
  ProtVar
URL;VALUE=URI:https://www.ebi.ac.uk/training/events/discovery-and-variant-e
 ffect-prediction-next-generation-protvar
END:VEVENT
END:VCALENDAR