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VERSION:2.0
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BEGIN:VEVENT
DTSTAMP:20260615T052058Z
UID:984c8cb0-bd00-463b-9ccb-a2a97102ce36
DTSTART:20251113T090000Z
DTEND:20251113T170000Z
DESCRIPTION:ProtVar integrates human variant annotations and predictions to
  uncover the functional effects of missense variation in humans. Learn how
  our diverse data and intuitive visualisations can help you to contextuali
 se your variant list or browse and prioritise variants from our expansive 
 database.Genomic variation can perturb normal biological processes through
  diverse and context-dependent mechanisms\, necessitating the integration 
 of multi-dimensional datasets to accurately interpret their effects. Prote
 in coding variation\, in particular\, offers unique opportunities beyond c
 linical diagnostics\, such as the identification of therapeutic targets an
 d engineering applications in synthetic biology. However\, it also introdu
 ces significant interpretative complexity\, contributing to the high propo
 rtion of missense variants that remain of uncertain significance.ProtVar i
 s a human variant annotation and assessment web tool developed at EMBL-EBI
 \, designed to offer users exceptional flexibility\, accessibility\, and s
 eamless integration. It aggregates data and analyses from a wide range of 
 resources to provide comprehensive genomic\, protein sequence\, functional
 \, and structural insights\, facilitating a deeper understanding of the po
 tential impact of missense variation in humans. This webinar will provide 
 practical guidance on how to explore and interact with ProtVar’s diverse
  annotations and predictive features to contextualise human missense varia
 nts. It will cover the types of annotations available\, the visualisations
  offered\, and the various methods for retrieving and exporting data.
LOCATION:\, 
SUMMARY:Evaluating variant effects in human proteins with ProtVar
URL;VALUE=URI:https://www.ebi.ac.uk/training/events/evaluating-variant-effe
 cts-human-proteins-protvar
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