BEGIN:VCALENDAR VERSION:2.0 PRODID:icalendar-ruby CALSCALE:GREGORIAN BEGIN:VEVENT DTSTAMP:20260719T192914Z UID:4bcd1b22-961b-47ac-a7c3-88385da0f03f DTSTART:20210916T090000Z DTEND:20210916T170000Z DESCRIPTION:Personalised Medicine (PerMed) opens unexplored frontiers to tr eat diseases at the individual level combining clinical and omics informat ion. However\, the performances of the current simulation software are sti ll insufficient to tackle medical problems such as tumour evolution or pat ient-specific treatments. The challenge is to develop a sustainable roadma p to scale-up the essential software for the cell-level simulation to the new European HPC/Exascale systems. Simulation of cellular mechanistic mode ls are essential for the translation of omic data to medical relevant acti ons and these should be accessible to the end-users in the appropriate env ironment of the PerMed-specific big confidential data. The goal of [PerMed CoE](https://permedcoe.eu/) is to provide an efficient and sustainable ent ry point to the HPC/Exascale-upgraded methodology to translate omics analy ses into actionable models of cellular functions of medical relevance.\n\n It will accomplish so by:\n\n1. Optimising four core applications for cell -level simulations to the new pre-exascale platforms\;\n2. Integrating Per Med into the new European HPC/Exascale ecosystem\, by offering access to H PC/Exascale-adapted and optimised software\;\n3. Running a comprehensive s et of PerMed use cases including simulations of tumour evolution and drug combinations for cancer treatment\; &\;\n4. Building the basis for the sustainability of the PerMedCoE by coordinating PerMed and HPC communities \, and reaching out to industrial and academic end-users\, with use cases\ , training\, expertise\, and best practices.\n\nThe PerMedCoE cell-level s imulations will fill the gap between the molecular- and organ-level simula tions from the other CoEs with which this project is aligned at different levels. It will connect method developers with HPC\, HTC and HPDA experts. Finally\, PerMedCoE will work with biomedical consortia and pre-exascale infrastructures\, including a substantial co-design effort.\n\n### About t he speaker\n\n[Alfonso Valencia](https://www.bsc.es/valencia-alfonso) is a Spanish biologist\, ICREA Professor\, current director of the Life Scienc es department at Barcelona Supercomputing Center (BSC) and of Spanish Nati onal Bioinformatics Institute (INB-ISCIII). He received his PhD in molecul ar biology in 1988 from the Autonomous University of Madrid. From 1989 to 1994 he was a Postdoctoral Fellow in the laboratory of Chris Sander at the European Molecular Biology Laboratory (EMBL) in Heidelberg\, studying the evolution of protein function using sequence- and structure-based approac hes. In 1994 Valencia formed the Protein Design Group at the Spanish Natio nal Center for Biotechnology (CNB). He was leader of the Structural and Co mputational Biology Group at Spanish National Cancer Research Center (CNIO ). From 2015-2018\, he was President of the International Society for Comp utational Biology (ISCB). As computational biologist\, the focus of his wo rk is the mechanistic understanding of biological systems\, including canc er and other diseases\, with a combination of Bioinformatics\, Network Bio logy and Machine Learning approaches. His group has developed systems in t he areas of protein structure prediction\, protein interactions and protei n networks\, systems biology\, text and data mining\, with applications in epigenetic\, cancer genomics and disease comorbidity. All these activitie s converge into the general topic of Personalised Medicine\, with particul ar interest in the interface with Artificial intelligence and High Perform ance Computing. SUMMARY:Introduction to PerMedCoE: Exascale-ready cell-level simulations fo r European Personalised Medicine URL;VALUE=URI:https://www.ebi.ac.uk/training/events/exascale-ready-cell-lev el-simulations-european-personalised-medicine-0 END:VEVENT END:VCALENDAR