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DTSTAMP:20260925T075256Z
UID:b16f7374-3d9f-4138-bacc-7b4aac7653d4
DTSTART:20270119T090000Z
DTEND:20270119T170000Z
DESCRIPTION:Bacteriophages\, viruses that only infect bacteria\, are Earth
 ’s most abundant and diverse biological entities. Their genomes represen
 t the largest untapped source of novel enzymes that function under extreme
  conditions. Among these\, endolysins (phage-encoded peptidoglycan hydrola
 ses) are of huge interest as eco-friendly antimicrobial agents. Endolysins
  can be utilised in the food\, agricultural and sanitation industries as a
 lternatives to harsh chemicals and detergents\, owing to their antimicrobi
 al activities over a range of conditions. New cold-adapted endolysins offe
 r the potential of energy-saving low-temperature cleaning\, whilst thermop
 hilic variants have potential use in fermentation\, food processing and as
  low-resistance alternatives to antibiotics. In this webinar I will discu
 ss research from my PhD project\, in which I combined AlphaFold and other 
 predictive methods with biophysical and experimental techniques to investi
 gate putative cold-adapted and thermophilic endolysins. Sequences of inter
 est were obtained from metagenomic sources of Icelandic hot springs and Ar
 ctic seawater. I will highlight how these investigations revealed unexpect
 ed and novel structural features within the enzyme class\, the evolutionar
 y implications of this\, and the potential for biotechnological applicatio
 ns and rational design.
LOCATION:\, 
SUMMARY:Metagenomic discovery of novel antimicrobial enzymes from Earth’s
  extremes
URL;VALUE=URI:https://www.ebi.ac.uk/training/events/metagenomic-discovery-n
 ovel-antimicrobial-enzymes-earths-extremes
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