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DESCRIPTION:**The video of the lecture can be found in the [SIB YouTube cha
 nnel](https://youtu.be/GAe2kKRsxGM).\n**\n\n# Overview\n[Rhea](https://www
 .rhea-db.org/) is an expert-curated knowledgebase of chemical and transpor
 t reactions of biological interest and the standard for enzyme and transpo
 rter annotation in [UniProtKB](https://www.uniprot.org/). Rhea uses the ch
 emical dictionary [ChEBI](https://www.ebi.ac.uk/chebi/) (Chemical Entities
  of Biological Interest) to describe reaction participants. Rhea provides 
 computationally tractable enzyme annotations in UniProtKB that support che
 mical ontology and structure based searches in the UniProt website\, REST 
 API\, and SPARQL endpoint. Rhea also provides reaction data for a host of 
 other resources including ChEBI\, MetaboLights\, Reactome\, and The Gene O
 ntology\, which now bases enzyme molecular functions on Rhea. Rhea and Uni
 ProtKB are SIB resources\; they are listed in [Expasy](https://www.expasy.
 org/)\, the Swiss Bioinformatics Portal.\n\nThe goal of this course is to 
 provide basic theoretical and practical knowledge that will enable partici
 pants to mine enzyme data in UniProtKB using chemical structure data and c
 hemical classifications from Rhea and ChEBI.\n\n# Audience\nThis course is
  addressed to biologists\, bioinformaticians\, cheminformaticians\,  progr
 ammers and data scientists working with enzyme and small molecule data\, i
 ncluding those working with metabolomics data and metabolic networks.\n\n#
  Learning outcomes\nAt the end of the course\, the participants are expect
 ed to:\n* have acquired a good understanding of the structure and design o
 f the chemical ontology ChEBI and the reaction knowledgebase Rhea\, and ho
 w they are used in UniProtKB annotation\n* be able to search UniProtKB and
  Rhea using chemical ontology terms and chemical structures - including ex
 act chemical structure searches\, as well as substructure and similarity s
 earches\, using interactive and programmatic means (REST API and SPARQL). 
 \n* have acquired a basic understanding of how to use RDF and SPARQL for i
 ntegration of chemical and biological data in UniProt with other key knowl
 edgebases and data repositories providing RDF and SPARQL endpoints.  \n\n#
  Prerequisites\n##### Knowledge / competencies\nThis course is designed fo
 r beginners with a basic knowledge of biology and chemistry.\n##### Techni
 cal\nThis course will be streamed\, you are thus required to have your own
  computer with an Internet connection.\n\n# Registration\nAttendance is fr
 ee-of-charge\, however registration is mandatory (see the Apply button bel
 ow). To attend the practical session on March 3\, 2022\, register [here](h
 ttps://www.sib.swiss/training/course/20220303_RHEAP).\n\nThere is no limit
  on the number of participants. All registered participants will receive o
 ne day before\, by email the information for remotely connecting to the on
 line meeting room.\n\n# Venue and Time\nThis course will be streamed using
  Zoom. \n\nThe course will start at 15:00 CET and end around 18:00 CET. Pr
 ecise information will be provided to the participants in due time.\n\n# S
 chedule (CET)\n15h00 - 16h45: Introduction : main concepts and resources\n
 - Small molecules / ChEBI\n- Biochemical and transport reactions / Rhea\n-
  Enzyme classification / ENZYME (EC numbers)\n- Enzyme and transporter seq
 uences / UniProtKB\n\n16h45-17h00 Break\n\n17h00-17h20 Search in UniProt (
 web and REST API)\n17h20-17h40 Search in Rhea (web and REST API)\n\n17h40-
 18h00: Semantic web : RDF/SPARQL (short introduction + query examples)\n\n
 \n#  Additional information\nCoordination: Monique Zahn\, SIB Training Gro
 up.\n\nYou are welcome to register to the SIB courses mailing list to be i
 nformed of all future courses and workshops\, as well as all important dea
 dlines using the form [here](https://lists.sib.swiss/mailman/listinfo/cour
 ses).\n\nPlease note that participation in SIB courses is subject to our [
 general conditions](https://www.sib.swiss/training/terms-and-conditions).\
 n\nSIB abides by the [ELIXIR Code of Conduct](https://elixir-europe.org/ev
 ents/code-of-conduct). Participants of SIB courses are also required to ab
 ide by the same code.\n\nFor more information\, please contact [training@s
 ib.swiss](mailto://training@sib.swiss).
LOCATION:SIB
SUMMARY:Mining enzyme data in UniProtKB using Rhea
URL;VALUE=URI:https://www.sib.swiss/training/course/20220224_RHEAL
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