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DTSTAMP:20260719T075136Z
UID:490d0861-18bb-4649-9a67-cdebb3e07e93
DTSTART:20231107T090000Z
DTEND:20231107T170000Z
DESCRIPTION:The tumour microenvironment encompasses many different cell typ
 es including cancer cells\, stromal cells\, immune cells\, and the extrace
 llular matrix (ECM)\, that interact and collectively influence cancer prog
 ression and treatment outcomes.  \nRecently\, computational mathematical m
 odels have been proved efficient in testing hypotheses and giving insights
  about tumour microenvironment functionalities. Among those\, hybrid multi
 scale models combine different techniques that simulate both inter- and in
 tra-cellular interactions.  \nIn this context\, we present a 3D model of c
 ancer cell invasion\, aiming to study the different modes of cell migratio
 n through the extracellular matrix and to predict means to block it by con
 sidering spatial information\, molecules’ diffusion and intracellular re
 gulation.  \nThe model was constructed using PhysiBoSS\, a multiscale fram
 ework\, which combines agent-based modelling and continuous time Markov pr
 ocesses applied on Boolean network models.  \nOur multiscale model success
 fully reproduces single and collective migration processes reported in pub
 lished experiments on cell invasion. These experiments include various asp
 ects such as the role of p63 expression in regulating MT1-MMP\, the spatio
 -temporal activation of SRC triggering collective migration\, and the infl
 uence of different collagen densities on invasion modes. In silico experim
 ents can be performed to suggest potential targets capable of inhibiting h
 ighly invasive tumour phenotypes.\n\n### About the speaker\n\n[Marco Rusco
 ne](https://www.linkedin.com/in/marco-ruscone-530b35192/) is a PhD student
  in the Computation Systems Biology of Cancer group at Institut Curie\, Pa
 ris. He started his academic career in Turin\, Italy\, where he pursued hi
 s bachelor degree in Physics and master degree in Physics of Complex Syste
 ms for the Biology\, at Università degli Studi di Torino.  \nCurrently\, 
 his work focuses on developing multiscale models of cancer using a mixed a
 pproach of agent-based modelling and simulation on Boolean networks.
LOCATION:\, 
SUMMARY:Multiscale model of the different modes of invasion: a PhysiBoSS ap
 plication
URL;VALUE=URI:https://www.ebi.ac.uk/training/events/multiscale-model-differ
 ent-modes-invasion-physiboss-application
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