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DTSTAMP:20260615T033958Z
UID:fafaf16b-aa4d-417d-a7aa-1af1564dea36
DTSTART:20230426T070000Z
DTEND:20230428T150000Z
DESCRIPTION:Epitranscriptome refers to all chemical modifications affecting
  cellular RNAs. Although more than 170 different types have been identifie
 d up to now\, their punctual detection is yet challenging. Profiling epitr
 anscriptome modifications require ad hoc sequencing technologies as well a
 s dedicated computational workflows. While Illumina RNAseq is the de facto
  sequencing methodology for unveiling RNA editing events (not transient mo
 difications)\, Nanopore direct RNA Sequencing has recently become one of t
 he most powerful techniques to profile the whole repertoire of RNA modific
 ations. Its capacity to directly sequence full-length\, native RNA molecul
 es without the need for retrotranscription or amplification offers remarka
 ble advantages compared to other technologies based on short-read sequenci
 ng. However\, at the same time it poses various experimental and analytica
 l challenges. This course will provide a foundation on the experimental pl
 anning\, analytical strategies and computational approaches for applying N
 anopore direct RNA Sequencing to profile RNA modifications. Through a comb
 ination of theoretical lectures and practical exercises\, participants wil
 l learn the fundamental concepts and bioinformatics skills that will allow
  them to start using Nanopore sequencing data for epitranscriptome analysi
 s. Additionally\, the course will also cover theoretical aspects of RNA ed
 iting as well as practical sessions focused on its detection in human/mous
 e transcriptomes by Illumina RNAseq data. Participants will acquire specif
 ic skills in command-line tools (REDItools) to call\, annotate (REDIportal
 ) and filter RNA variants. \n\nSpeakers\nEva Novoa (CRG\, ES)\nMattia Peli
 zzola (IIT\, IT)\n\nInstructors\nAdriano Fonzino (UNIBA\, IT)\nClaudio Lo 
 Giudice (UNIBA\, IT)\nAlessandro Silvestris (UNIBA\, IT)\nFrancesco Nicass
 io (IIT\, IT)\nErnesto Picardi (UNIBA\, IT)\nTommaso Leonardi (IIT\, IT)\n
 Camilla Ugolini (IIT\, IT)\nLogan Mulroney (IIT\, IT)\n\nHelpers\nPietro D
 ’Addabbo (UNIBA\, IT)\nChiara Bruno (CNR\, IT)\n\n
LOCATION:Via Giovanni Amendola\, 122o\, 122o Via Giovanni Amendola
SUMMARY:Training Course in Computational Methods for Epitrascriptomics
URL;VALUE=URI:https://elixir-iib-training.github.io/website/2023/04/26/Comp
 utational_Methods_for_Epitrascriptomics_Bari.html
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