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DTSTAMP:20260715T222319Z
UID:2b60a79f-c96a-427c-9ab1-5bb07102f50a
DTSTART:20231010T170000Z
DTEND:20231010T170000Z
DESCRIPTION:You are invited to join the webinar from the 3D-BioInfo Commun
 ity\n\n\n	\n		\n			\n				Dr. Joana Pereira\, \n\n				Biozentrum\, Univers
 ity of Basel \n\n				(joana.pereira@unibas.ch)\n			\n			  \n		\n	\n\n\n
 "Uncovering new families and folds in the natural protein universe"\n\nAbs
 tract:\n	“Thanks to the deep learning revolution in bioinformatics\, we 
 are now entering a new era in protein structural biology. There are hundre
 ds of millions of predicted protein structures made available through the 
 AlphaFold database\, which cover nearly all proteins that are known. This 
 include not only those already covered by the PDB but also those that are 
 challenging to computationally annotate for function or putative biologica
 l role. We examined the extent to which the AlphaFold database has structu
 rally illuminated this “dark matter” of the natural protein universe a
 t high predicted accuracy and described the protein diversity that they co
 ver as an annotated interactive sequence similarity network. By searching 
 for novelties from sequence\, structure\, and annotation perspectives\, we
  uncovered new novel folds\, found a new superfamily of translation-target
 ing toxin-antitoxin systems\, and added multiple protein families to Pfam.
  Our work underscores the value of large-scale efforts in identifying\, an
 notating\, and prioritising novel protein families. By leveraging this rev
 olution\, we can now shed light into uncharted areas of the protein univer
 se at an unprecedented scale.”\n\n\n	\n		\n			\n				 \n\n				Dr. Manjee
 t Kumar\,\n\n				European Molecular Biology Laboratory\n\n				(manjeet.kum
 ar@embl.de)\n			\n			\n				\n		\n	\n\n\n“Eukaryotic Linear Motif (ELM) r
 esource - updates\, annotation challenges\, and impact of AlphaFold2 and A
 lphaFold DB on motif-mediated PPIs”\n	Abstract:\n	The talk will cover re
 cent updates on the Eukaryotic Linear Motif (ELM) resource\, a hub for exp
 loring the Short Linear Motifs (SLiMs). Other than sharing the latest biol
 ogical insights from the database\, I will also discuss the challenges enc
 ountered during the annotation process\, including distinguishing function
 ally relevant motifs and the missing cellular context. The last part of th
 e talk will focus on the impact of AlphaFold2 (AF2)/AlphaFold predicted mo
 dels (AFDB) in advancing our understanding of motif-mediated protein-prote
 in interactions (PPIs) and their functional relevance.\n\n\n	\n		\n			\n		
 		 \n\n				This webinar will be chaired by \n\n				Dr. Mihaly Varadi\,\n
 \n				European Bioinformatics Institute\n\n				(mvaradi@ebi.ac.uk)\n			\n	
 		\n		\n	\n\n\nAll previous webinars from the 3d-BioInfo Community are ava
 ilable here
SUMMARY:Webinar: New Era of Structure Abundance - Insights into Protein Fun
 ction
URL;VALUE=URI:https://www.elixir-europe.org/events/webinar-new-era-structur
 e-abundance-insights-protein-function
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