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DTSTAMP:20260618T093434Z
UID:373c55c9-db63-45c1-9db8-1f7c72232ead
DTSTART:20190615T090000Z
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DESCRIPTION:In this workshop\, we will introduce Open Targets Genetics Port
 al as part of the Open Targets ecosystem\, highlighting variant-centric st
 atistical evidence for prioritizing candidate causal variants at trait-ass
 ociated loci\, and identifying potential drug targets. We will present POS
 TGAP\, a pipeline which merges genetic associations curated from literatur
 e with functional genomics\, epigenetic and expression data (e.g.\, eQTL\,
  promoter capture Hi-C\, DNase hypersensitivity sites\, regulatory element
 s) to resolve association signals at a locus and link each variant to its 
 target gene(s) using a single evidence score. The portal also incorporates
  pre-computed fine-mapping at trait-associated loci across hundreds of UK 
 Biobank phenotypes as well as cross-trait colocalization\, furthering drug
  repurposing opportunities. This workshop will enable you to effectively u
 se Open Targets Genetics to gain biological insight\, prioritize genes\, a
 nd inform target decision-making. Intended Audience: Attendees interested 
 in the translational application of genetics and genomics with an emphasis
  on the identification of target genes of trait-associated loci\, drug tar
 get identification\, prioritisation and repurposing. Participants should b
 ring their laptops for exploration of the Open Targets Genetics Portal in 
 situ.
LOCATION:Gothenburg
SUMMARY:Open Targets Genetics at ESHG
URL;VALUE=URI:https://2019.eshg.org/index.php/programme/saturday/
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