Workshops and courses

ELIXIR node event Exploring protein biophysics with B2BTools and Scop3P

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Date: 19 January 2026 @ 09:00 - 17:00

Language of instruction: English

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Protein function depends on dynamics - not just static structures. While AlphaFold2 revolutionized structural biology by predicting near-complete protein structures, its models provide only a single snapshot. This course introduces tools that go further by exploring sequence-based biophysical properties such as disorder, dynamics, and folding propensity. You will learn how to use B2BTools to predict these features and Scop3P to assess the structural and functional impact of phosphorylation sites. By combining structural predictions with dynamics insights, you will gain a deeper understanding of protein flexibility and function. Both tools are developed and maintained by the ELIXIR Belgium node, making them freely accessible for academics users. 

Keywords: advanced bioinformatics, Artificial Inteligence, ELIXIR

Venue: Ghent - VIB/UGent FSVM II, Technologiepark 75

City: Zwijnaarde

Country: Belgium

Postcode: 9052

Learning objectives:

  • Able to correlate biophysical properties to post-translational modifications (PTMs)
  • Calculate and analyse protein biophysical profiles for sequence-based data
  • Compare the impact on protein dynamics by introducing mutations with B2BTools
  • Perform exploratory structural analysis combining the AlphaFold predictions with biophysical profiles generated by the B2BTools

Organizer: VIB

Event types:

  • Workshops and courses

Sponsors: ELIXIR Belgium

Instructors: Adrián Díaz, Pathmanaban Ramasamy

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