ChEMBL is a database of bioactive drug-like small molecules, it contains 2-D structures, calculated properties (e.g. logP, Molecular Weight, Lipinski Parameters, etc.) and abstracted bioactivities (e.g. binding constants, pharmacology and ADMET data). This webinar will provide an overview of the ChEMBL API and its use, including how to execute API calls from the browser; where to find documentation; how to user filtering and pagination; available output formats; and scripting examples in Python, Bash and R.